Cardiac Electrophysiology
Simulator

What is openCARP?

openCARP is an open cardiac electrophysiology simulator for in-silico experiments. Its source code is public and the software is freely available for academic purposes. openCARP is easy to use and offers single cell as well as multiscale simulations from ion channel to organ level. Additionally, openCARP includes a wide variety of functions for pre- and post-processing of data as well as visualization. The python-based CARPutils framework enables the user to develop and share simulation pipelines, i.e. automating in-silico experiments including all modeling/simulation steps.

News

openCARP paper published

The paper "The openCARP simulation environment for cardiac electrophysiology" recently published in Computer Methods and Programs in Biomedicine gives a comprehensive overview of the openCARP simulation environment. Check it out here and cite if you use openCARP!

openCARP 4th user meeting

The 4th openCARP user meeting will be held from the 20th to the 22nd of September 2021 in Karlsruhe, Germany. Registrations are now open and are limited to 60 people. Please register on https://forms.gle/S4kU5kVUPJM6rpJt9. For more information visit the user meeting webpage.

openCARP online user meeting

On 14th of April 2021, between 4 pm and 7 pm CEST, we are having another intermediate online openCARP user meeting. If you want to join the user meeting, please register on https://forms.gle/k24rj3kE9P1PJWD37

Older news

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User Meeting

The 4th openCARP workshop will take on the 20-22 of September this year in Karlsruhe, Germany. Registration is now open until September 8. Further information about openCARP workshops can be found in the section openCARP user meeting. Stay informed and subsribe to our newsletter!

Quick facts

To ensure input compatibility with CARP/CARPentry allowing to reproduce a larger number of published studies, the user interface of openCARP has been designed to be backwards compatible, thus facilitating the re-use and replication of a large number of previous studies and carefully crafted in silico experiments. The underlying code basis has been redeveloped from scratch. As this software is a community project, you are welcome to contribute.

Our aim is to increase the productivity in our research field. We believe that you should invest your time in actually solving a scientific problem (rather than spending your precious time developing yet another simulator). With openCARP, you can import CellML-based EP models to avoid error-prone and time-demanding manual implementation. Additionally, we will offer the service to upload in silico experiments (based on CARPutils) of your published studies to share it with your colleagues for a more transparent and better reproducable cardiac modeling research.

The openCARP collaboration

The implementation of openCARP builds on two decades of experience gained from the proprietary predecessors, the Cardiac Arrhythmia Research Package (CARP) developed by Ed Vigmond and Gernot Plank and acCELLerate developed by Gunnar Seemann and Axel Loewe. Both simulators have been used in 100+ scientific studies. Gunnar Seemann (Freiburg, Germany) and Axel Loewe (Karlsruhe, Germany) received funding from the German Research Foundation (DFG) to develop a sustainable cardiac simulator. They asked Ed Vigmond (Bordeaux, France) and Gernot Plank (Graz, Austria) to join forces which they agreed to in March 2018. Since then, we have been developing openCARP and have released the first version in March 2020. Beside the four group leaders, the core developer Aurel Neic from NumeriCor joined the openCARP steering committee in November 2019.

Liryc KIT    UHZ Med-Uni-Graz numeriCor

Attribution

If you use this software, please cite the paper describing it as below. Specific versions of the software can additionally be referenced using individual DOIs. When presenting work based on openCARP, we suggest to display our logo.

Plank, G., Loewe A., Neic. A et al. (2021). The openCARP simulation environment for cardiac electrophysiology. Computer Methods and Programs in Biomedicine 2021;208:106223. doi:10.1016/j.cmpb.2021.106223

@article{openCARP,
author = {Gernot Plank and Axel Loewe and Aurel Neic and Christoph Augustin and Yung-Lin Huang and Matthias A.F. Gsell and Elias Karabelas, Mark Nothstein, Jorge Sanchez and Anton J Prassl and Gunnar Seemann and Edward J Vigmond},
title = {The {openCARP} Simulation Environment for Cardiac Electrophysiology},
pages = {106223},
volume = {208},
journal = {Computer Methods and Programs in Biomedicine},
doi = {10.1016/j.cmpb.2021.106223}, 
year = {2021}
}

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