Community experiments

2022 Simulation code

Example of reentry induction in a 2D idealized infarct model (v1.0)

Campos, Fernando ; Neic, Aurel ; Mendonca Costa, Caroline ; Whitaker, John; O’Neill, Mark; Razavi, Reza; A. Rinaldi, Christopher; Scherr, Daniel ; Niederer, Steven A. ; Plank, Gernot ; Bishop, Martin J.

This is an idealized 2D cardiac infarct model designed with the purpose of replicating the setup used in our study entitled "An automated near-real time computational method for induction and treatment of scar-related ventricular tachycardias" (accepted) Medical Image Analysis (2022). This is an idealized 2D cardiac infarct model designed with the purpose of replicating the setup used in our study entitled "An automated near-real time computational method for induction and treatmen… show more show less

https://doi.org/10.35097/606

Life Science Computer Science Medicine cardiac electrophysiology openCARP experiment in-silico medicine computational cardiology

2022 Simulation code

In Silico Characterization of the Sinoatrial Node (v2.0)

Sanchez, Jorge ; Amsaleg, Antoine; Loewe, Axel

In silico experiments to study the sinoatrial node characteristics. The experiment script is able to modify several electrophysiological parameters using as an input a vtk file.

https://doi.org/10.35097/763

Life Science Computer Science Medicine cardiac electrophysiology openCARP experiment in-silico medicine computational cardiology

2022 Simulation code

Single human myocyte simulations of KCNQ1 mutants (v1.0)

Loewe, Axel ; Nagel, Claudia

Single cell simulations of KCNQ1 mutants using human myocyte models. Use external/runAll.py to launch all simulations.

https://doi.org/10.35097/580

Life Science Computer Science Medicine cardiac electrophysiology openCARP experiment in-silico medicine computational cardiology

2025

Sympathetic Stimulation Can Compensate for Hypocalcaemia-Induced Bradycardia in Human and Rabbit Sinoatrial Node Cells (v1.0)

Linder, Moritz ; Loewe, Axel

This experiment simulates the extended sinoatrial node cell models of Severi et al. (2012) and Fabbri et al. (2017) with several [Ca2+]o and [ISO]. The extension of the AC-cAMP-PKA signalling cascade is based on the work of Behar et al. (2016). This experiment simulates the extended sinoatrial node cell models of Severi et al. (2012) and Fabbri et al. (2017) with several [Ca2+]o and [ISO]. The extension of the AC-cAMP-PKA signalling cascade … show more show less

https://doi.org/10.35097/qec954fvka86gcjw

Biology cardiac electrophysiology openCARP experiment in-silico medicine computational cardiology sinoatrial node cell models autonomic regulation cAMP-PKA signalling coupled clock system Computer simulation biomedical engineering cardiology LifeScience ComputerScience Medicine

2023 Simulation code

The Right Atrium Affects In Silico Arrhythmia Vulnerability in Both Atria

Martinez Diaz, Patricia ; Loewe, Axel

This is an example to run the PEERP (Pacing at the End of the Refractory Period, Luca Azzolin et al., https://doi.org/10.3389/fphys.2021.656411) protocol using a monoatrial left atrium (LA) mesh, with fibers and region annotation. The mesh is the mean LA geometry from the SSM (Statistical Shape Model) proposed by Claudia Nagel et al. ([doi:10.5281/zenodo.4309957](https://doi.org/10.5281/zenodo.4309957)) and the fibers and annotations were generated using AugmentA code https://github.com/KIT-IBT/AugmentA (https://doi.org/10.1016/j.compmedimag.2023.102265) by Luca Azzolin et al. This is an example to run the PEERP (Pacing at the End of the Refractory Period, Luca Azzolin et al., https://doi.org/10.3389/fphys.2021.656411) protocol using a monoatrial left atrium (LA) mesh, with… show more show less

https://doi.org/10.35097/1830

Engineering Medicine Computer Science cardiac electrophysiology openCARP experiment in-silico medicine computational cardiology right atrium arrhythmia vulnerability

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